Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research pursuits contain:
Human Rad51 filaments on double- and solitary-stranded DNA: correlating normal and irregular varieties with recombination function.
Back again in 1991, Sumio Iijima on the NEC Company experienced documented the synthesis of carbon nanotubes. Band framework calculations instructed that these nanotubes could show metallic band conduction. This may be a big gain about the conducting polymers we had explored, which had been, in reality, disordered semiconductors supplying simply variable-assortment hopping conductivity.
2007, 1st serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
2015, discovery that condensin can be a really flexible protein construction; and to start with detection of DNA knots working with nanopores
From the several years adhering to these discoveries, my exploration passions shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The focus of many scientists in the sector also shifted to graphene (exactly where, funnily enough, the main graphene ribbons ended up referred to as ‘nanotubes which are cut open up alongside their length’) immediately after the discovery of the two-dimensional product in 2004.
Length Charge of individual carbon nanotubes by nanostructuring with the scanning tunneling microscope
Dynamic ParB–DNA interactions initiate and keep a partition condensate for bacterial chromosome segregation
Let's say, instead of making use of regular leading-down silicon electronics, transistors may be crafted from the bottom up making use of solitary natural and organic molecules as the switching factors? This concept, which grew to become the basis of right now’s discipline of molecular electronics, to start with emerged in the 1970s.
It was through this period that Dekker completed research on magnetic spin programs and on noise in superconductors and semiconductors.
An integrated microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
‘That problems the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter appeared best-down in those days and recognized about five hundred genes which can be minimally required for the operating cell. We want to look bottom-up: how do we transfer from the handful of molecules to an entire Organic method?
2005, discovery from the system ceesdekker.net of DNA uncoiling by topoisomerase enzymes; discovery of long-assortment conformational variations in Mre11/DNA fix complexes; and to start with power measurements with a DNA molecule within a nanopore
‘I'm pushed by wonder and concerns. On a fabric degree I uncover responses in physics, but I working experience my deepest happiness with God. That faith also drives my science and how I cope with folks.