Nanotechnology features a range of possibilities to contribute to biology. Listed here I will current illustrations wherever nanofabrication – a chance to make confined structures with dimensions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:
You frequently get involved in conversations about science and faith. You have got also composed several textbooks on the subject. Don’t you believe that at some point We are going to know every little thing Which God’s part will be in excess of?
[Laughs] ‘It absolutely was unquestionably an awesome hazard! At some time, I had been properly mindful that it could go Mistaken and that I could turn out to be much less effective, but I just ignored that. Curiosity has normally been my strongest driving pressure. And by chance it all worked out.’
2007, 1st serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
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Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in crimson, and a 3D rendering with the motion of your DNA rod is shown.
We form microorganisms into types that deviate from their all-natural phenotype. ceesdekker.net Specifically, I'll exhibit our capacity to shape live E. coli microbes into novel styles for example rectangles, squares, triangles and circles.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA in a cooperative style
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Resolving the step size in condensin-driven DNA loop extrusion identifies ATP binding as the move-building system
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes
As an example, we look at the nucleopore elaborate, a gateway involving the cell nucleus and the cytoplasm. This is a really challenging method and thus difficult to review in the cell, so we use biomimetics. We reconstruct holes after which you can insert specific components of your nucleopore advanced to study transportation by means of it at The one-molecule stage.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)